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Authors: Iżykowska J., Skupin M., Andrzejewska W., Dobies M., Jurga S., Kozak M.

Ttle: Carbon nanostructures of different spatial geometry: their dispersion and influence on model biological systems

Source: Biophysical Journal Year : 2017

Abstract:

The discovery of carbon nanostructures (CN) in the last century has revolutionized science, opening new research opportunities in biophysics, material sciences, biomedicine and pharmacology [1]. Unfortunately, carbon nanomaterials show a strong tendency towards aggregation and poor stability in solutions. Such properties, especially the suspension stability, are critical for bio-applications of carbon nanostructures [2]. Surface functionalization of nanocarbons improves the dispersing properties in water solutions but it may also influence their physicochemical properties [3]. For preparation of biocompatible CN samples we used novel dicationic surfactant (gemini) with imidazole head groups. Nanocarbon suspensions were investigated in the context of their anticancer activity, as well as their application as multimodal contrast/drug delivery agents. Different spatial geometries of CN may be of key importance for designing of the efficient anti-cancer system. Such systems were subjected to the cytotoxicity tests on HeLa cell cultures. The structural properties of selected, the most effective systems based on CN suspensions were characterized by the use of SEM, AFM and NMR methods. This study was supported by the Ministry of Science and Higher Education (Poland), within the project ?Najlepsi z najlepszych!?

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